Which prefix signifies a condition tied to stones or calculi?

The prefix that signifies a condition tied to stones or calculi is "litho-." This prefix is derived from the Greek word "lithos," which means stone. It is commonly used in medical terminology to refer to stones or calcifications that can form in various organs or parts of the body, such as the kidneys (nephrolithiasis for kidney stones) or the gallbladder (cholelithiasis for gallstones).

In contexts involving medical conditions, "litho-" is typically associated with pathology relating to the formation of calculi, making it the most appropriate choice for this question. Understanding the role of this prefix can help in recognizing and interpreting various medical terms related to conditions involving stones, which is essential for those studying in the field of healthcare.